ARHGEF18 antibody (AA 501-600) (Cy3)

Catalog No. ABIN1702420

Product Details anti-ARHGEF18 Antibody (Cy3)

Target: ARHGEF18 (rho/rac Guanine Nucleotide Exchange Factor (GEF) 18 (ARHGEF18))

Binding Specificity: AA 501-600

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARHGEF18 antibody is conjugated to Cy3

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ARHGEF18/p114RhoGEF

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for ARHGEF18

Target: ARHGEF18 (rho/rac Guanine Nucleotide Exchange Factor (GEF) 18 (ARHGEF18))

Alternative Name: ARHGEF18 (ARHGEF18 Products)

Background:

Synonyms: 114 kDa Rho specic guanine nucleotide exchange factor, ARHGEF 18, ARHGEF18, KIAA0521, MGC15913, p114 Rho GEF, p114-Rho-GEF, Rho specic guanine nucleotide exchange factor p114, Rho-specic guanine nucleotide exchange factor p114, Rho/Rac guanine nucleotide exchange factor GEF 18, Rho/Rac guanine nucleotide exchange factor 18, SA RhoGEF, Septin associated RhoGEF, ARHGI_HUMAN.

Background: Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). The protein encoded by this gene is a guanine nucleotide exchange factor and belongs to the Rho GTPase GFE family. Family members share a common feature, a Dbl (DH) homology domain followed by a pleckstrin (PH) homology domain. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008].

Gene ID: 23370

Pathways: Neurotrophin Signaling Pathway