ARHGEF18 antibody (AA 159-551)

Catalog No. ABIN7167973

Product Details anti-ARHGEF18 Antibody

Target: ARHGEF18 (rho/rac Guanine Nucleotide Exchange Factor (GEF) 18 (ARHGEF18))

Binding Specificity: AA 159-551

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARHGEF18 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Rho guanine nucleotide exchange factor 18 protein (159-551AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ARHGEF18

Target: ARHGEF18 (rho/rac Guanine Nucleotide Exchange Factor (GEF) 18 (ARHGEF18))

Alternative Name: ARHGEF18 (ARHGEF18 Products)

Synonyms: arhgef18 antibody, wu:fc21e04 antibody, wu:fj05f11 antibody, zgc:85686 antibody, P114-RhoGEF antibody, AI467246 antibody, D030053O22Rik antibody, rho/rac guanine nucleotide exchange factor (GEF) 18a antibody, Rho/Rac guanine nucleotide exchange factor (GEF) 18 antibody, Rho/Rac guanine nucleotide exchange factor 18 antibody, rho guanine nucleotide exchange factor 18 antibody, rho/rac guanine nucleotide exchange factor (GEF) 18 antibody, arhgef18a antibody, ARHGEF18 antibody, LOC100027283 antibody, Arhgef18 antibody

Background:

Background: Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). p114RgoGEF cts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. It may play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It also act as a GEF for RAC1, inducing production of reactive oxygen species (ROS), but does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production.

Aliases: 114 kDa Rho specific guanine nucleotide exchange factor antibody, 114 kDa Rho-specific guanine nucleotide exchange factor antibody, ARHGEF 18 antibody, Arhgef18 antibody, ARHGI_HUMAN antibody, KIAA0521 antibody, MGC15913 antibody, p114 Rho GEF antibody, p114-Rho-GEF antibody, p114RhoGEF antibody, Rho guanine nucleotide exchange factor 18 antibody, Rho specific guanine nucleotide exchange factor p114 antibody, Rho/Rac guanine nucleotide exchange factor (GEF) 18 antibody, Rho/Rac guanine nucleotide exchange factor 18 antibody, SA RhoGEF antibody, SA-RhoGEF antibody, Septin associated RhoGEF antibody, Septin-associated RhoGEF antibody

UniProt: Q6ZSZ5

Pathways: Neurotrophin Signaling Pathway