SNX5 antibody (AA 2-75) (Cy3)

Catalog No. ABIN1702543

This Rabbit Polyclonal antibody specifically detects SNX5 in WB, IF (cc) and IF (p). It exhibits reactivity toward Human.

Quick Overview for SNX5 antibody (AA 2-75) (Cy3) (ABIN1702543)

Target: SNX5 (Sorting Nexin 5 (SNX5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SNX5 antibody is conjugated to Cy3

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-SNX5 Antibody (Cy3)

Binding Specificity: AA 2-75

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SNX5

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for SNX5

Target: SNX5 (Sorting Nexin 5 (SNX5))

Alternative Name: SNX5

Background:

Synonyms: 0910001N05Rik, 1810032P22Rik, AU019504, D2Ertd52e, FLJ10931, OTTHUMP00000030340, OTTHUMP00000062927, OTTMUSP00000003367, OTTMUSP00000003368, RP11-504H3.2, RP23-35E16.2, snoRNA MBI-43, SNX 5, SNX5, SNX5_HUMAN, Sorting nexin 5, Sorting nexin-5.

Background: Sorting nexin 1 (SNX1) is a member of a large family of hydrophilic proteins that interact with a variety of receptor types and are involved in intracellular trafficking (1). SNX1 and the related splice variant, SNX1A, bind the epidermal growth factor (EGF) receptor, facilitate its transport to lysosome, and thereby contribute to the degradation of the receptor (2,3). SNX2 and SNX4 share a high degree of amino acid similarity with SNX1, as they all contain a characteristic phox homology (PX) domain (4). These proteins are all partially associated with cellular membranes, and they, likewise, associate with EGF, PDGF and insulin receptor tyrosine kinases (2). These nexins are widely expressed and yet have various tissue distribution patterns. Additionally, the sorting nexins can associate with each other and with a variety of other cellular proteins, suggesting that they exist as part of multisubunit complexes (1,5). The related protein, SNX3, comprises a distinct subgroup of nexins that share less sequence similarity outside of the PX domain and have dramatically different binding affinities for the tyrosine kinase receptors (2,6).

Gene ID: 27131