GAS2 antibody (AA 141-240) (Cy5)

Catalog No. ABIN1703927

The Rabbit Polyclonal anti-GAS2 antibody has been validated for IF (cc) and IF (p). It is suitable to detect GAS2 in samples from Human.

Quick Overview for GAS2 antibody (AA 141-240) (Cy5) (ABIN1703927)

Target: GAS2 (Growth Arrest-Specific 2 (GAS2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GAS2 antibody is conjugated to Cy5

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-GAS2 Antibody (Cy5)

Binding Specificity: AA 141-240

Predicted Reactivity: Human,Mouse,Rat,Cow,Sheep,Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GAS2

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for GAS2

Target: GAS2 (Growth Arrest-Specific 2 (GAS2))

Alternative Name: GAS2

Background:

Synonyms: GAS 2, GAS-2, Gas2, GAS2_HUMAN, Growth arrest specic 2, Growth arrest specic protein 2, Growth arrest-specic protein 2, MGC32610.

Background: Gas2 is a 313 amino acid protein encoded by the human gene GAS2. Gas2 is thought to play a role in apoptosis by acting as a cell death substrate for caspases. Gas2, a component of the microfilament system, is cleaved by a caspase (caspase-3 and caspase-7) at Asparagine 278 during apoptosis. The cleaved form resulting from this dramatically induces the rearrangement of the Actin cytoskeleton and causes potent changes in the shape of the affected cells. Gas2 is believed to also be involved in the membrane ruffling process. During the G0-G1 transition phase Gas2 can be found phosphorylated on its serine residues. Gas2 is a cytoskeleton and peripheral membrane protein that co-localizes with Actin fibers at the cell border and along the stress fibers in growth-arrested fibroblasts. Gas2 is mainly membrane-associated but when hyperphosphorylated it will accumulate at membrane ruffles. Gas2 is specifically expressed at growth arrest and is ubiquitously expressed with highest levels found in liver, lung and kidney. There is no evidence, however, of Gas2 expression in spleen.

Gene ID: 2620

Pathways: Caspase Cascade in Apoptosis