MAML3 antibody (AA 931-1030) (Cy5)

Catalog No. ABIN1705165

This Rabbit Polyclonal antibody specifically detects MAML3 in IF (cc) and IF (p). It exhibits reactivity toward Human.

Quick Overview for MAML3 antibody (AA 931-1030) (Cy5) (ABIN1705165)

Target: MAML3 (Mastermind-Like 3 (MAML3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAML3 antibody is conjugated to Cy5

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-MAML3 Antibody (Cy5)

Binding Specificity: AA 931-1030

Predicted Reactivity: Human,Mouse,Rat,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MAML3

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for MAML3

Target: MAML3 (Mastermind-Like 3 (MAML3))

Alternative Name: MAML3

Background:

Synonyms: AV234550, BC049812, CAGH3, ERDA3, GDN, KIAA1816, MAM 2, MAM2, mastermind like 3 Drosophila, MGC59565, mKIAA1816, TNRC3, MAML3_HUMAN.

Background: The three MAML genes are widely expressed in adult tissues but exhibit distinct expression patterns in mouse early spinal cord development. All MAML proteins localize to nuclear bodies, share a conserved basic domain in their N termini that binds to the ankyrin repeat domain of Notch, and contain a transcriptional activation domain in their C termini. MAML3 acts as a transcriptional coactivator for NOTCH proteins and has been shown to amplify NOTCH-induced transcription of HES1.