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BOP1 antibody (AA 201-300) (Cy5.5)

This Rabbit Polyclonal antibody specifically detects BOP1 in WB, IF (cc) and IF (p). It exhibits reactivity toward Mouse.
Catalog No. ABIN1706050

Quick Overview for BOP1 antibody (AA 201-300) (Cy5.5) (ABIN1706050)

Target

See all BOP1 Antibodies
BOP1 (Block of Proliferation 1 (BOP1))

Reactivity

  • 20
  • 19
  • 5
  • 4
  • 4
  • 3
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Mouse

Host

  • 34
Rabbit

Clonality

  • 34
Polyclonal

Conjugate

  • 14
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This BOP1 antibody is conjugated to Cy5.5

Application

  • 27
  • 12
  • 12
  • 5
  • 4
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • Binding Specificity

    • 14
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 201-300

    Cross-Reactivity

    Mouse

    Predicted Reactivity

    Human,Rat,Dog,Cow,Sheep,Pig,Chicken

    Purification

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human BOP1

    Isotype

    IgG
  • Application Notes

    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Preservative

    ProClin

    Precaution of Use

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Storage

    -20 °C

    Storage Comment

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Expiry Date

    12 months
  • Target

    BOP1 (Block of Proliferation 1 (BOP1))

    Alternative Name

    BOP1

    Background

    Synonyms: AU020183, AW146150, Block of proliferation 1, Block of proliferation 1 protein, Bop1, Bop1 block of proliferation 1, BOP1_HUMAN, D18861, Erb1p, Kiaa0124, MGC109114, mKIAA0124, Ribosome biogenesis protein BOP1.

    Background: Predominantly localized to the nucleolus, BOP1 (Block of proliferation 1 protein) is a 746 amino acid highly conserved non-ribosomal protein that is involved in ribosome biogenesis. Truncation of the amino terminus of BOP1 leads to cell growth arrest in the G1 phase and specific inhibition of 28S and 5.8S rRNA synthesis, as well as a deficit in the cytosolic 60S ribosomal subunit. This suggests that BOP1 is involved in the formation of mature rRNAs and in the biogenesis of the 60S ribosomal subunit. BOP1 physically interacts with pescadillo (a protein involved in cell proliferation) and enables efficient incorporation of pescadillo into the nucleolar preribosomal complexes, thereby affecting rRNA maturation and the cell cycle. The BOP1-pescadillo complex is also necessary for biogenesis of 60S ribosomal subunits. Deregulation of BOP1 may lead to colorectal tumorigenesis.

    Gene ID

    23246
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