GEMIN6 antibody (AA 21-120) (HRP)

Catalog No. ABIN1711328

The Rabbit Polyclonal anti-GEMIN6 antibody has been validated for WB, ELISA, IHC (fro) and IHC (p). It is suitable to detect GEMIN6 in samples from Human and Rat.

Quick Overview for GEMIN6 antibody (AA 21-120) (HRP) (ABIN1711328)

Target: GEMIN6 (Gem (Nuclear Organelle) Associated Protein 6 (GEMIN6))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GEMIN6 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-GEMIN6 Antibody (HRP)

Binding Specificity: AA 21-120

Cross-Reactivity: Human, Rat

Predicted Reactivity: Mouse,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Gemin 6

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for GEMIN6

Target: GEMIN6 (Gem (Nuclear Organelle) Associated Protein 6 (GEMIN6))

Alternative Name: Gemin 6

Background:

Synonyms: FLJ23459, Gemin6, Gemin-6, Gem nuclear organelle associated protein 6, Gem-associated protein 6, GEMI6, GEMI6_HUMAN, Gemin-6, GEMIN6, SIP2.

Background: Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disease characterized by loss of motor neurons in the spinal cord. SMA is caused by deletion or loss-of-function mutations in the SMN (Survival of Motor Neuron) gene. Gemin6, the protein product of human chromosome 2p22.2, associates directly with SMN and is a part of the SMN complex containing Gemin2, Gemin3, Gemin4 and Gemin5 as well as several spliceosomal snRNP proteins. The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing of the nucleus. The SMN complex is found in both the cytoplasm and the nucleus. The nuclear form is concentrated in subnuclear bodies called gems (Gemini of the coiled bodies).

Gene ID: 79833

Pathways: Ribonucleoprotein Complex Subunit Organization