BMP8B antibody (AA 311-402) (HRP)

Catalog No. ABIN1711630

This Rabbit Polyclonal antibody specifically detects BMP8B in WB, ELISA, IHC (p) and IHC (fro). It exhibits reactivity toward Human.

Quick Overview for BMP8B antibody (AA 311-402) (HRP) (ABIN1711630)

Target: BMP8B (BMP8) (Bone Morphogenetic Protein 8B (BMP8))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BMP8B antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-BMP8B Antibody (HRP)

Binding Specificity: AA 311-402

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human BMP8b

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for BMP8B

Target: BMP8B (BMP8) (Bone Morphogenetic Protein 8B (BMP8))

Alternative Name: BMP8b

Background:

Synonyms: BMP-8, BMP-8B, BMP8, Bmp8b, BMP8B_HUMAN, Bone morphogenetic protein 8, Bone morphogenetic protein 8B, OP-2, OP2, Osteogenic protein 2.

Background: Bone morphogenic proteins (BMPs) are members of the TGF Beta superfamily. BMPs are involved in the induction of cartilage and bone formation. In vivo studies have shown that BMP-2 (also designated BMP-2A) and BMP-3 can independently induce cartilage formation. Smad3 association with the TGF Beta receptor complex and Smad1 translocation to the nucleus are observed after the addition of BMP-4 (also designated BMP-2B), suggesting that BMP-4 may play a role in activation of the Smad pathway. BMP-5, BMP-6 and BMP-7 all share high sequence homology with BMP-2, indicating that they each may be able to induce cartilage formation. BMP-8 (also designated OP-2) is thought to be involved in early development, as detectable expression has not been found in adult organs.

Gene ID: 656