BMP8B antibody (Internal Region)

Catalog No. ABIN7224384

The Rabbit Polyclonal anti-BMP8B antibody is suitable to detect BMP8B in samples from Human and Mouse. It has been validated for ELISA, IHC and IF.

Quick Overview for BMP8B antibody (Internal Region) (ABIN7224384)

Target: BMP8B (BMP8) (Bone Morphogenetic Protein 8B (BMP8))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BMP8B antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-BMP8B Antibody

Binding Specificity: Internal Region

Purpose: Rabbit Anti-BMP-8 Polyclonal Antibody

Specificity: BMP-8 Polyclonal Antibody detects endogenous levels of BMP-8 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human BMP-8

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:100-1:300,ELISA 1:40000,IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for BMP8B

Target: BMP8B (BMP8) (Bone Morphogenetic Protein 8B (BMP8))

Alternative Name: BMP-8

Background: BMP8B, BMP8, Bone morphogenetic protein 8B, BMP-8, BMP-8B, Osteogenic protein 2, OP-2, BMP8A, Bone morphogenetic protein 8A, BMP-8ABMP8B (bone morphogenetic protein 8b) encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The encoded protein stimulates thermogenesis in brown adipose tissue. Expression of BMP8B may be downregulated in pancreatic cancer. BMP8B may have arose from a gene duplication event and its gene duplicate is also present on chromosome 1.

Gene ID: 656

UniProt: P34820, Q7Z5Y6