FPGS antibody (AA 51-150) (HRP)

Catalog No. ABIN1711961

The Rabbit Polyclonal anti-FPGS antibody has been validated for WB, ELISA, IHC (p) and IHC (fro). It is suitable to detect FPGS in samples from Human.

Quick Overview for FPGS antibody (AA 51-150) (HRP) (ABIN1711961)

Target: FPGS (Folylpolyglutamate Synthase (FPGS))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FPGS antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-FPGS Antibody (HRP)

Binding Specificity: AA 51-150

Predicted Reactivity: Human,Mouse,Rat,Dog,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human FPGS/Folylpolyglutamate synthase

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for FPGS

Target: FPGS (Folylpolyglutamate Synthase (FPGS))

Alternative Name: FPGS/Folylpolyglutamate synthase

Background:

Synonyms: EC 6.3.2.17, FOLC, FOLC_HUMAN, Folylpoly gamma glutamate synthetase, Folylpoly-gamma-glutamate synthetase, Folylpolyglutamate synthase, Folylpolyglutamate synthase mitochondrial, FPGS, mitochondrial, OTTHUMP00000022201, OTTHUMP00000022202, Tetrahydrofolate synthase, Tetrahydrofolylpolyglutamate synthase.

Background: This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. While several transcript variants may exist for this gene, the full-length natures of only two have been biologically validated to date. These two variants encode distinct isoforms. [provided by RefSeq, Jul 2008].

Gene ID: 2356