GEMIN4 antibody (AA 251-350) (HRP)

Catalog No. ABIN1711970

The Rabbit Polyclonal anti-GEMIN4 antibody has been validated for WB, ELISA, IHC (p) and IHC (fro). It is suitable to detect GEMIN4 in samples from Human.

Quick Overview for GEMIN4 antibody (AA 251-350) (HRP) (ABIN1711970)

Target: GEMIN4 (Gem (Nuclear Organelle) Associated Protein 4 (GEMIN4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GEMIN4 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-GEMIN4 Antibody (HRP)

Binding Specificity: AA 251-350

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Gemin 4

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for GEMIN4

Target: GEMIN4 (Gem (Nuclear Organelle) Associated Protein 4 (GEMIN4))

Alternative Name: Gemin 4

Background:

Synonyms: Gemin4, Gemin-4, Component of gems 4, Gem associated protein 4, HC56, HHRF 1, GEMI4_HUMAN.

Background: Gemin4 is a component of the SMN core complex which, while in the cytoplasm, plays an essential role in ribonucleoprotein (snRNP) assembly, including the biogenesis, delivery and recycling of snRNPs to the spliceosome. In the nucleus, where SMN is required for pre-mRNA splicing, Gemin4 concentrates next to coiled bodies in subnuclear structures called gems, that are highly enriched in splicosomal snRNPs, and in the nucleolus. Deletion or loss-of-function mutations in the SMN lead to the neurodegenerative disease spinal muscular atrophy (SMA). The human Gemin4 maps to chromosome 17p13.

Gene ID: 50628

Pathways: Ribonucleoprotein Complex Subunit Organization