FOSB antibody (pSer27) (HRP)

Catalog No. ABIN1712099

The Rabbit Polyclonal anti-FOSB antibody has been validated for WB and ELISA. It is suitable to detect FOSB in samples from Human.

Quick Overview for FOSB antibody (pSer27) (HRP) (ABIN1712099)

Target: FOSB (FBJ Murine Osteosarcoma Viral Oncogene Homolog B (FOSB))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FOSB antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA

Product Details anti-FOSB Antibody (HRP)

Binding Specificity: pSer27

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Guinea Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human Fos B around the phosphorylation site of Ser27

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for FOSB

Target: FOSB (FBJ Murine Osteosarcoma Viral Oncogene Homolog B (FOSB))

Alternative Name: FosB

Background:

Synonyms: Fos B phospho S27, p-Fos B phospho S27, p-FosB phospho S27, FBJ murine osteosarcoma viral oncogene homolog B, FOS B, FOS-B, FBJ osteosarcoma oncogene B, FosB, G0/G1 switch regulatory protein 3, G0S3, GOS3, GOSB, MGC42291, Oncogene FOS B, Protein fosB, fosB, G0/G1 switch regulatory protein 3, G0S3, GOS 3, GOS B, GOSB, Oncogene FOS B, Oncogene FOSB, Protein fos B, DKFZp686C0818, FOSB_HUMAN.

Background: The v-Fos oncogene was initially identified as the transforming gene of two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. The cellular homolog, c-Fos, encodes a nuclear phosphoprotein that is rapidly and transiently induced by a variety of agents and functions as a transcriptional regulator for several genes. In contrast to c-Jun proteins, which form homo- and heterodimers which bind to specific DNA TPA response elements (TREs), c-Fos proteins are only active as heterodimers with members of the Jun gene family. Murine Fos B encodes a nuclear protein of 338 amino acids which has 70 % homology with c-Fos, exhibits similar kinetics of expression as c-Fos and forms heterodimers with both c-Jun and Jun B which bind to TRE DNA response elements. Functional homologs of c-Fos and Fos B include Fra-1 and Fra-2 genes.

Gene ID: 2354