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SYPL1 antibody (AA 121-220) (HRP)

This Rabbit Polyclonal antibody specifically detects SYPL1 in WB, ELISA, IHC (p) and IHC (fro). It exhibits reactivity toward Mouse.
Catalog No. ABIN1712563

Quick Overview for SYPL1 antibody (AA 121-220) (HRP) (ABIN1712563)

Target

SYPL1 (Synaptophysin-Like 1 (SYPL1))

Reactivity

  • 18
  • 15
  • 4
  • 2
  • 2
  • 2
  • 1
Mouse

Host

  • 30
Rabbit

Clonality

  • 29
  • 1
Polyclonal

Conjugate

  • 12
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This SYPL1 antibody is conjugated to HRP

Application

  • 30
  • 13
  • 13
  • 10
  • 10
  • 5
  • 2
  • 2
  • 1
Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • Binding Specificity

    • 14
    • 8
    • 5
    • 2
    • 1
    AA 121-220

    Cross-Reactivity

    Mouse

    Predicted Reactivity

    Human,Rat,Cow,Pig,Rabbit

    Purification

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human Pantophysin

    Isotype

    IgG
  • Application Notes

    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Preservative

    ProClin

    Precaution of Use

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Handling Advice

    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

    Storage

    -20 °C

    Storage Comment

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Expiry Date

    12 months
  • Target

    SYPL1 (Synaptophysin-Like 1 (SYPL1))

    Alternative Name

    Pantophysin

    Background

    Synonyms: SYPL1_HUMAN, Synaptophysin-like protein 1, Pantophysin, SYPL1, H-SP1, SYPL.

    Background: The MARVEL domain is a 130 amino acid motif that contains four transmembrane helices, both of which have cytoplasmic N- and C-terminal regions. MARVEL domain-containing proteins are thought to participate in tight junction regulation, the biogenesis of vesicular transport carriers and in cholesterol-rich membrane apposition events. Pantophysin, also known as SYPL1 (synaptophysin-like protein 1) or H-SP1, is a 259 amino acid multi-pass membrane protein that localizes to melanosomes and vesicles, as well as to the cytoplasm, and contains one MARVEL domain. Expressed as multiple alternatively spliced isoforms, pantophysin is present in tissues throughout the body where it may play a role in vesicle trafficking and protein transport. The gene encoding pantophysin maps to human chromosome 7, which houses over 1,000 genes and comprises nearly 5 % of the human genome. Defects in some of the genes localized to chromosome 7 have been linked to Osteogenesis imperfecta, Williams-Beuren syndrome, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome.

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