BOC antibody (PE)

Catalog No. ABIN1712708

The Rabbit Polyclonal anti-BOC antibody has been validated for FACS. It is suitable to detect BOC in samples from Human, Rat and Mouse.

Quick Overview for BOC antibody (PE) (ABIN1712708)

Target: BOC (Brother Of CDO (BOC))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BOC antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-BOC Antibody (PE)

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Protein BOC

Isotype: IgG

Application Details

Application Notes: FCM: 1:20-100
Optimal working dilution should be determined by the investigator.

Comment:

Exitation/Emission: 480,565nm/578nm

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at 4 °C

Expiry Date: 12 months

Target Details for BOC

Target: BOC (Brother Of CDO (BOC))

Alternative Name: Protein Boc

Background:

BOC is a receptor-like, single pass membrane protein belonging to the cell surface molecule subfamily of the Immunoglobulin/fibronectin type-III repeat family within the immunoglobulin superfamily. It contains three fibronectin type-III domains and four Immunoglobulin-like C2-type domains in its extracellular region. The intracellular region of BOC is not required for proper function. BOC localizes to the cell membrane and is ubiquitously expressed with highest expression levels in skeletal muscle and small intestine. Its mRNA expression is down-regulated by Ras. BOC is involved in accelerating myoblast differentiation and is dependent on CDO for its activity. BOC and CDO are co-expressed in muscle precursors and are components of a receptor complex that mediates cell-cell interactions important in myogenesis. Overexpression of BOC results in enhanced differentiation of myoblast cells. In addition, BOC is a target and signaling component of the Shh pathway.

Subcellular location: Extracellular

Synonyms: Boc homolog mouse, Brother of CDO, Protein BOC, brother of CDO precursor, Protein BOC, BOC_HUMAN.

Gene ID: 91653

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development