CDON antibody (PE)

Catalog No. ABIN1712743

This Rabbit Polyclonal antibody specifically detects CDON in FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for CDON antibody (PE) (ABIN1712743)

Target: CDON (Cell Adhesion Molecule-Related/down-Regulated By Oncogenes (CDON))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDON antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-CDON Antibody (PE)

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CDON

Isotype: IgG

Application Details

Application Notes: FCM(1:20-100)

Comment:

Exitation/Emission: 480,565nm/578nm

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at 4°C

Expiry Date: 12 months

Target Details for CDON

Target: CDON (Cell Adhesion Molecule-Related/down-Regulated By Oncogenes (CDON))

Alternative Name: Cdon

Background:

Cell adhesion molecule-related/down-regulated by oncogenes (CDO) and BOC (brother of CDO) are members of the immunoglobulin/fibronectin type III repeat family and act as cell surface receptors. CDO is a component of a cell-surface receptor complex which also contains BOC, NEO1, CTNNB1 and cadherins and which acts as a mediator of cell-cell interactions between muscle cells. CDO and BOC are single pass membrane proteins that play a role in myogenic cell differentiation. Together, CDO and BOC participate in a positive feedback loop with MyoD, a myogenic transcription factor. The 1,242 amino acid rat CDO protein has a 24 residue signal sequence, five Ig V-like repeats, a 25 residue membrane-spanning region, three FNIII-like repeats and a cytoplasmic region of 256 amino acids containing a proline-rich stretch. The human protein contains 1,225 amino acid residues and shares significant homology with the domain structures of the rat protein.

Subcellular location: Extracellular

Synonyms: CDO, CDON, Cell adhesion molecule-related/down-regulated by oncogenes, CDON_HUMAN.

Gene ID: 50937

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Embryonic Body Morphogenesis