GPBAR1 antibody (PE-Cy5.5)

Catalog No. ABIN1713077

The Rabbit Polyclonal anti-GPBAR1 antibody has been validated for WB. It is suitable to detect GPBAR1 in samples from Human.

Quick Overview for GPBAR1 antibody (PE-Cy5.5) (ABIN1713077)

Target: GPBAR1 (G Protein-Coupled Bile Acid Receptor 1 (GPBAR1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GPBAR1 antibody is conjugated to PE-Cy5.5

Application: Western Blotting (WB)

Product Details anti-GPBAR1 Antibody (PE-Cy5.5)

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GPBAR1

Isotype: IgG

Application Details

Application Notes: FCM(1:100-500)
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for GPBAR1

Target: GPBAR1 (G Protein-Coupled Bile Acid Receptor 1 (GPBAR1))

Alternative Name: GPCR TGR5/GPBAR1

Background:

Synonyms: BG 37, BG37, G protein coupled bile acid receptor 1, G protein coupled bile acid receptor BG 37, G protein coupled bile acid receptor BG37, G-protein coupled bile acid receptor 1, G-protein coupled receptor GPCR19, GPBAR 1, GPBAR_HUMAN, GPBAR1, GPCR 19, GPCR, GPCR19, GPR 131, GPR131, hBG 37, hBG37, hGPCR 19, hGPCR19, M BAR, M-BAR, Membrane bile acid receptor, Membrane type receptor for bile acids, Membrane-type receptor for bile acids, MGC40597, TGR 5, TGR5.

Background: The G protein-coupled receptor TGR5 is a 330-amino acid protein that is almost universally expressed in human tissues including heart, skeletal muscle, spleen, kidney, liver, small intestine, placenta, and leukocytes, but not in brain, colon (without mucosa), thymus, or lung. TGR5 is sensitive to bile acids and responds through a significant mechanism that coordinates energy homeostasis. Bile acids activate mitogen-activated protein (MAP) kinase pathways, specifically induce TGR5 internalization, promote an increase of guanosine 5'-O-3-thio-triphosphate binding in membrane fractions, and cause rapid intracellular cAMP production. Bile acids also provoke TGR5 to suppress macrophage functions. TGR5-controlled signaling pathways may be good candidates for drug targets to treat common metabolic diseases, such as obesity, type II diabetes, hyperlipidemia, and atherosclerosis.

Gene ID: 151306

Pathways: WNT Signaling, Hormone Transport, Sensory Perception of Sound