METTL18 antibody (AA 121-220)

Catalog No. ABIN1714121

The Rabbit Polyclonal anti-METTL18 antibody has been validated for IF (cc), IF (p), ELISA, IHC (fro), IHC (p) and ICC. It is suitable to detect METTL18 in samples from Human.

Quick Overview for METTL18 antibody (AA 121-220) (ABIN1714121)

Target: METTL18 (Methyltransferase Like 18 (METTL18))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This METTL18 antibody is un-conjugated

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Product Details anti-METTL18 Antibody

Binding Specificity: AA 121-220

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human C1orf156

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for METTL18

Target: METTL18 (Methyltransferase Like 18 (METTL18))

Alternative Name: C1orf156

Background:

Synonyms: Arsenic-transactivated protein 2, AsTP2, Histidine protein methyltransferase 1 homolog, HPM1, MET18_HUMAN, Methyltransferase like 18, Methyltransferase-like protein 18, Mettl18, MGC9084, RP1-117P20.4.

Background: Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8 % of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma. The C1orf156 gene product has been provisionally designated C1orf156 pending further characterization.

Gene ID: 92342