GCHFR antibody (AA 21-60)

Catalog No. ABIN1714314

This anti-GCHFR antibody is a Rabbit Polyclonal antibody detecting GCHFR in ELISA, IF (cc), IF (p), IHC (p), ICC and IHC (fro). Suitable for Rat.

Quick Overview for GCHFR antibody (AA 21-60) (ABIN1714314)

Target: GCHFR (GTP Cyclohydrolase I Feedback Regulator (GCHFR))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GCHFR antibody is un-conjugated

Application: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-GCHFR Antibody

Binding Specificity: AA 21-60

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Cow,Pig,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GCHFR

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for GCHFR

Target: GCHFR (GTP Cyclohydrolase I Feedback Regulator (GCHFR))

Alternative Name: GCHFR

Background:

Synonyms: GCHFR, GFRP, GFRP_HUMAN, GTP cyclohydrolase 1 feedback regulatory protein, GTP cyclohydrolase I feedback regulator, GTP cyclohydrolase I feedback regulatory protein, HsT16933, MGC138467, MGC138469, p35.

Background: GTP cyclohydrolase I feedback regulatory protein (GFRP) is encoded by the gene GCHFR. GFRP mediates feedback inhibition of GTP cyclohydrolase I activity by tetrahydrobiopterin. GFRP also acts as a mediator for the stimulatory effect of phenylalanine on enzyme activity. L-phenylalanine reverses this inhibition. The molecular weight of GFRP is approximately 9.5 kDa although cross-linking experiments have shown that GFRP is usually found as a homodimer or as a pentamer. 15q15.

Gene ID: 2644