Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

FZD8 antibody

The Rabbit Polyclonal anti-FZD8 antibody has been validated for WB, IHC (p) and IF (p). It is suitable to detect FZD8 in samples from Human, Mouse and Rat.
Catalog No. ABIN1714370

Quick Overview for FZD8 antibody (ABIN1714370)

Target

See all FZD8 Antibodies
FZD8 (Frizzled Family Receptor 8 (FZD8))

Reactivity

  • 60
  • 47
  • 35
  • 5
  • 4
  • 2
  • 1
  • 1
  • 1
Human, Mouse, Rat

Host

  • 58
  • 3
  • 2
  • 1
Rabbit

Clonality

  • 54
  • 10
Polyclonal

Conjugate

  • 30
  • 4
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This FZD8 antibody is un-conjugated

Application

  • 40
  • 19
  • 15
  • 10
  • 10
  • 6
  • 2
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • Cross-Reactivity

    Human, Mouse, Rat

    Purification

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human Frizzled 8

    Isotype

    IgG
  • Application Notes

    WB: (1:100-1000), FCM: (1:20-100), IHC-P: (1:100-500), IF(IHC-P): (1:50-200)
    Optimal working dilution should be determined by the investigator.

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    -20 °C

    Storage Comment

    Store at -20°C for 12 months.

    Expiry Date

    12 months
  • Target

    FZD8 (Frizzled Family Receptor 8 (FZD8))

    Alternative Name

    Frizzled 8

    Background

    Synonyms: Frizzled 8 seven transmembrane spanning receptor, frizzled 8, seven transmembrane spanning receptor, Frizzled family receptor 8, frizzled homolog 8 Drosophila, Frizzled homolog 8, Frizzled-8, FZ 8, Fz-8, FZ8, FZD 8, FZD8, FZD8_HUMAN, hFZ 8, hFZ8, HGNC4046, Homolog of Drosophila Frizzled 8.

    Background: The frizzled gene, originally identified in Drosophila melanogaster, is involved in the development of tissue polarity. The mammalian homolog of frizzled, as well as several secreted mammalian frizzled-related proteins (FRPs), have been described. The frizzled proteins contain seven transmembrane domains, a cysteine-rich domain in the extracellular region and a carboxy-terminal Ser/Thr-xxx-Val motif. They function as receptors for Wnt and are generally coupled to G proteins. The cysteine-rich domain of frizzled-8 blocks endogenous Wnts and the effects of Wnt-1 and Wnt-5 on proliferation. The mouse frizzled-8 gene, which encodes a Wnt receptor, is a potent cancer-associated activator of the Beta-catenin-TCF pathway. The frizzled-8 gene contains no introns. Frizzled-8 mRNA has been detected in fetal brain and kidney, and also in adult pancreas, skeletal muscle, kidney and heart. Frizzled is highly expressed in HeLa S3 (cervical uterus cancer) cells and A549 lung cancer cells.

    Gene ID

    8325

    Pathways

    WNT Signaling
You are here:
Chat with us!