FGFR3 antibody (pTyr724)

Catalog No. ABIN1714583

The Rabbit Polyclonal anti-FGFR3 antibody has been validated for WB. It is suitable to detect FGFR3 in samples from Human.

Quick Overview for FGFR3 antibody (pTyr724) (ABIN1714583)

Target: FGFR3 (Fibroblast Growth Factor Receptor 3 (FGFR3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FGFR3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FGFR3 Antibody

Binding Specificity: pTyr724

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Cow,Sheep,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human FGFR3 around the phosphorylation site of Tyr724

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for FGFR3

Target: FGFR3 (Fibroblast Growth Factor Receptor 3 (FGFR3))

Alternative Name: FGFR3

Background:

Synonyms: FGFR3 phospho Y724, FGFR3 phospho Tyr724, p-FGFR3 phospho Y724, ACH, CD 333, CD333, CD333 antigen, CEK 2, CEK2, FGFR 3, Fibroblast growth factor receptor 3 achondroplasia thanatophoric dwarfism, Fibroblast growth factor receptor 3, Heparin binding growth factor receptor, HSFGFR3EX, Hydroxyaryl protein kinase, JTK 4, JTK4, MFR 3, SAM 3, Tyrosine kinase JTK 4, Tyrosine kinase JTK4, Z FGFR 3.

Background: The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used, adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.

Gene ID: 2261

UniProt: P22607

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance, Growth Factor Binding