SPTA1 antibody (AA 2151-2350)

Catalog No. ABIN1714958

The Rabbit Polyclonal anti-SPTA1 antibody has been validated for WB and ELISA. It is suitable to detect SPTA1 in samples from Mouse and Rat.

Quick Overview for SPTA1 antibody (AA 2151-2350) (ABIN1714958)

Target: SPTA1 (Spectrin alpha 1, Erythrocytic (SPTA1))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPTA1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-SPTA1 Antibody

Binding Specificity: AA 2151-2350

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Spectrin alpha chain, erythrocytic 1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for SPTA1

Target: SPTA1 (Spectrin alpha 1, Erythrocytic (SPTA1))

Alternative Name: Spectrin alpha chain, erythrocytic 1

Background:

Synonyms: Alpha I spectrin, EL 2, EL2, Elliptocytosis 2, Elliptocytosis2, Erythrocyte alpha spectrin, erythrocyte, Erythroid alpha spectrin, Erythroid alpha-spectrin, Erythroid spectrin alpha, HPP, HS3, Spectrin alpha chain, Spectrin alpha chain erythrocyte, Spectrin alpha erythrocytic 1, SPH3, SPTA 1, SPTA, SPTA1, SPTA1_HUMAN, Spectrin alpha chain, erythrocytic 1.

Background: Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia. [provided by RefSeq, Jul 2008].

Gene ID: 6708

Pathways: Regulation of Actin Filament Polymerization