TXNDC5 antibody (AA 52-63)

Catalog No. ABIN1721515

This Mouse Monoclonal antibody specifically detects TXNDC5 in WB, ELISA, IHC, IF, IP and ICC. It exhibits reactivity toward Human.

Quick Overview for TXNDC5 antibody (AA 52-63) (ABIN1721515)

Target: TXNDC5 (Thioredoxin Domain Containing 5 (Endoplasmic Reticulum) (TXNDC5))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TXNDC5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Clone: 2E7-7

Product Details anti-TXNDC5 Antibody

Binding Specificity: AA 52-63

Specificity: Reacts with human EndoPDI.

Purification: Purified (protein G)

Immunogen: Synthetic peptide corresponding to aa 52-63 (ADGEDGQDPHSK) of human EndoPDI (accession no. NP_001139021).

Isotype: IgG2a

Application Details

Application Notes: Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
ICC(1:10 - 1:500) IF(1:10 - 1:500) IHC(1:10 - 1:500) IP(1:10 - 1:500) WB(1 μg/mL)

Positive control: Heat-shocked HeLa cell lysate.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Dilute in PBS or medium which is identical to that used in the assay system.

Storage: -20 °C

Storage Comment: This antibody is stable for at least one year at -20°C. Avoid multiple freeze-thaw cycles.

Target Details for TXNDC5

Target: TXNDC5 (Thioredoxin Domain Containing 5 (Endoplasmic Reticulum) (TXNDC5))

Alternative Name: EndoPDI

Background: Endothelial protein disulfide isomerase (EndoPDI) is a thiredoxin member of the protein disulfide isomerase family of chaperones. This enzyme is localized in the endoplasmic reticulum in primary endothelial cells but colocalizes with nucleoli in the nuclei of breast, colon, and kidney cancer cells. EndoPDI mRNA and protein expression is iduced by hypoxia and exhibits a protective effect on endothelial cells during hypoxia.

Thioredoxin domain containing 5 (endoplasmic reticulum) Endoplasmic reticulum resident protein 46, ER protein 46, ERp46 Thioredoxin-like protein p46 HCC2, HCC-2 STRF8 PDIA15 UNQ364 Gene name :TXNDC5

Gene ID: 81567

UniProt: Q8NBS9

Pathways: Cell RedoxHomeostasis