GABBR2 antibody (AA 861-912)

Catalog No. ABIN1721530

This Mouse Monoclonal antibody specifically detects GABBR2 in WB and IHC. It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for GABBR2 antibody (AA 861-912) (ABIN1721530)

Target: GABBR2 (gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2))

Reactivity: Human, Rat, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This GABBR2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: S81-2

Product Details anti-GABBR2 Antibody

Binding Specificity: AA 861-912

Specificity: Reacts with human GABA(B)R2. Cross-reacts with mouse and rat protein. Do not cross-react with GABA(B)R1.

Purification: Purified (protein G)

Immunogen: Fusion protein corresponding to aa 861-912 of rat GABA(B)R2 (accession no. NP_113990.1).

Isotype: IgG1

Application Details

Application Notes: Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
IHC(1 -5 μg/mL) WB(1 - 2 μg/mL)

Positive control: Rat brain membranes.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, glycerol 50 % .

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Dilute in PBS or medium that is identical to that used in the assay system.

Storage: -20 °C

Storage Comment: Stable for at least one year at -20°C. Avoid multiple freeze-thaw cycles.

Expiry Date: 12 months

Target Details for GABBR2

Target: GABBR2 (gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2))

Alternative Name: GABA(B)R2

Background: GABA (γ-aminobutyric acid) is the primary inhibitory neurotransmitter in the central nervous system and interacts with three different receptors: GABA(A), GABA(B), and GABA(C). GABA(B) receptor is coupled to G proteins that modulate slow inhibitory synaptic transmission. Functional GABA(B) receptors form heterodimers of GABA(B)R1 and GABA(B)R2 in which GABA(B)R1 binds a ligand and GABA(B)R2 is the primary G protein contact site.

Gamma-aminobutyric acid type B receptor subunit 2 GABA-B receptor 2 GABA-B-R2, GABA-BR2, GABABR2, Gb2 G-protein coupled receptor 51 HG20 Gene name : GABBR2

Gene ID: 9568

UniProt: O75899

Pathways: cAMP Metabolic Process