Estrogen Receptor alpha antibody (Estrogen Receptor 1) (AA 410-592)

Details for Product anti-ESR1 Antibody No. ABIN1724648
Target
Binding Specificity
AA 410-592
43
31
29
27
26
24
23
21
21
18
17
16
16
16
15
15
15
13
11
11
10
8
7
6
5
5
5
5
4
4
4
4
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
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1
1
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1
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1
Reactivity
Human
593
255
206
40
33
12
10
9
7
7
5
5
4
3
3
1
1
Host
Mouse
453
176
2
1
1
Clonality (Clone)
Monoclonal ()
Conjugate
This Estrogen Receptor alpha antibody is un-conjugated
42
24
24
17
16
13
12
12
12
12
12
11
6
6
6
6
6
4
4
4
4
4
4
4
4
4
4
4
4
4
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
445
211
206
143
103
80
79
55
55
18
16
16
13
13
11
9
7
3
2
1
1
1
1
1
1
1
1
1
1
1
Options
Immunogen Purified recombinant fragment of human ER-alpha (410-592aa) expressed in E. Coli.
Clone 2B7
Isotype IgG1
Purification Purified
Target
Alternative Name ER-alpha (ESR1 Antibody Abstract)
Background The estrogen receptor (ER) is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. Alternative splicing results in several ER mRNA transcripts, which differ primarily in their 5-prime untranslated regions. Two isoforms of the human ER, ERA and ER-beta, occur, each with distinct tissue and cell patterns of expression. Pelletier and El-Alfy (2000) studied the immunocytochemical localization of ESRA and ESRB in human reproductive tissues. In the ovary, ERB immunoreactivity was found in nuclei of granulosa cells of growing follicles at all stages from primary to mature follicles, interstitial gland, and germinal epithelium cells. Nuclear staining for ERA occurred in thecal, interstitial gland, and germinal epithelium cells. In the uterus, strong ERA immunoreactivity was detected in nuclei of epithelial, stromal, and muscle cells.
Gene ID 2099
HGNC 2099
Pathways Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly
Application Notes ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 4°C, -20°C for long term storage
Images
Image no. 1 for anti-Estrogen Receptor 1 (ESR1) (AA 410-592) antibody (ABIN1724648) anti-Estrogen Receptor 1 (ESR1) (AA 410-592) antibody (Image 1)
Image no. 2 for anti-Estrogen Receptor 1 (ESR1) (AA 410-592) antibody (ABIN1724648) anti-Estrogen Receptor 1 (ESR1) (AA 410-592) antibody (Image 2)