BNP antibody

Catalog No. ABIN1724675

The Mouse Monoclonal anti-BNP antibody has been validated for IHC and ELISA. It is suitable to detect BNP in samples from Human. There are 2+ publications available.

Quick Overview for BNP antibody (ABIN1724675)

Target: BNP (Brain Natriuretic Peptide (BNP))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This BNP antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Clone: 8D5B4C11

Product Details anti-BNP Antibody

Purpose: BNP Antibody

Sequence: Cys-Phe-Gly-Arg-Lys-Met-Asp-Arg-Ile-Ser-Ser-Ser-Ser

Purification: Ascitic fluid

Immunogen: Synthetic peptide corresponding to aa (Cys-Phe-Gly-Arg-Lys-Met-Asp-Arg-Ile-Ser-Ser-Ser-Ser) of human BNP, conjugated to KLH.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-BNP antibody (ABIN1724675)

Dawson, Struthers: "Screening for treatable left ventricular abnormalities in diabetic patients." in: Expert opinion on biological therapy, Vol. 3, Issue 1, pp. 107-12, (2003) (PubMed).

Pfister, Erdmann, Schneider: "[Natriuretic peptides BNP and NT-pro-BNP--the "new troponins" for estimation of heart failure?]." in: Deutsche medizinische Wochenschrift (1946), Vol. 128, Issue 18, pp. 1007-12, (2003) (PubMed).

Target Details for BNP

Target: BNP (Brain Natriuretic Peptide (BNP))

Alternative Name: BNP

Background: BNP (brain natriuretic peptide) belongs to a family of structurally similar peptide hormones, which includes atrial natriuretic peptide (ANP), BNP, C-type natriuretic peptide (CNP) and urodilatin. ANP and BNP act mainly as cardiac hormones, produced primarily by the atrium and ventricle, respectively, while the gene encoding C-type natriuretic peptide is expressed mainly in the brain. BNP circulates in blood as a peptide hormone with natriuretic, vasodilatory and renin inhibitory properties. It is secreted predominantly by the left ventricular myocytes in response to volume expansion and pressure overload. These peptides are characterized by a common 17 amino acid ring structure with a disulfide bond between two cystein residues. This ring structure shows high homology between different natriuretic.

Gene ID: 4879

UniProt: P16860

Pathways: Hormone Activity