GM-CSF antibody (AA 18-144)

Catalog No. ABIN1724740

Product Details anti-GM-CSF Antibody

Target: GM-CSF (CSF2) (Colony Stimulating Factor 2 (Granulocyte-Macrophage) (CSF2))

Binding Specificity: AA 18-144

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GM-CSF antibody is un-conjugated

Application: ELISA

Purpose: CSF2 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human CSF2 (aa18-144) expressed in E. Coli.

Clone: 3D3

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-GM-CSF antibody (ABIN1724740)

He, Shumansky, Connett, Anthonisen, Paré, Sandford: "Association of genetic variations in the CSF2 and CSF3 genes with lung function in smoking-induced COPD." in: The European respiratory journal, Vol. 32, Issue 1, pp. 25-34, (2008) (PubMed).

Fuxman Bass, Alvarez, Gabelloni, Vermeulen, Amaral, Geffner, Trevani: "GM-CSF enhances a CpG-independent pathway of neutrophil activation triggered by bacterial DNA." in: Molecular immunology, Vol. 46, Issue 1, pp. 37-44, (2008) (PubMed).

Hansen, Hercus, McClure, Stomski, Dottore, Powell, Ramshaw, Woodcock, Xu, Guthridge, McKinstry, Lopez, Parker: "The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation." in: Cell, Vol. 134, Issue 3, pp. 496-507, (2008) (PubMed).

Target Details for GM-CSF

Target: GM-CSF (CSF2) (Colony Stimulating Factor 2 (Granulocyte-Macrophage) (CSF2))

Alternative Name: CSF2 (CSF2 Products)

Background: The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13.

Molecular Weight: 16 kDa

Gene ID: 1437

UniProt: P04141

Pathways: JAK-STAT Signaling, Cellular Response to Molecule of Bacterial Origin