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C17orf53 antibody (AA 282-527)

C17ORF53 Reactivity: Human WB, ELISA Host: Mouse Monoclonal 3E10H2 unconjugated
Catalog No. ABIN1724779
  • Target See all C17orf53 (C17ORF53) products
    C17orf53 (C17ORF53) (Chromosome 17 Open Reading Frame 53 (C17ORF53))
    Binding Specificity
    • 5
    • 1
    • 1
    • 1
    • 1
    AA 282-527
    Reactivity
    • 31
    • 15
    • 15
    • 3
    • 2
    • 2
    • 2
    • 1
    Human
    Host
    • 19
    • 12
    Mouse
    Clonality
    • 19
    • 12
    Monoclonal
    Conjugate
    • 10
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This C17orf53 antibody is un-conjugated
    Application
    • 24
    • 13
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    Purification
    purified
    Immunogen
    Purified recombinant fragment of human C17ORF53 (AA:282-527 ) expressed in E. coli.
    Clone
    3E10H2
    Isotype
    IgG1
  • Application Notes
    ELISA: 1:10000, WB: 1:500 - 1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    4°C, -20°C for long term storage
  • Styrkarsdottir, Halldorsson, Gretarsdottir, Gudbjartsson, Walters, Ingvarsson, Jonsdottir, Saemundsdottir, Snorradóttir, Center, Nguyen, Alexandersen, Gulcher, Eisman, Christiansen, Sigurdsson, Kong et al.: "New sequence variants associated with bone mineral density. ..." in: Nature genetics, Vol. 41, Issue 1, pp. 15-7, (2008) (PubMed).

  • Target
    C17orf53 (C17ORF53) (Chromosome 17 Open Reading Frame 53 (C17ORF53))
    Alternative Name
    C17ORF53 (C17ORF53 Products)
    Synonyms
    chromosome 17 open reading frame 53 antibody, C17orf53 antibody
    Background
    C17orf53 (chromosome 17 open reading frame 53) is a 647 amino acid protein that is encoded by a gene mapping to human chromosome 17. Chromosome 17 makes up over 2.5 % of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17. , ,
    Molecular Weight
    69.8 kDa
    Gene ID
    78995
    HGNC
    78995
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