Fc epsilon RI/FCER1A antibody (AA 42-103)

Catalog No. ABIN1724785

Product Details anti-Fc epsilon RI/FCER1A Antibody

Target: Fc epsilon RI/FCER1A (FCER1A) (Fc Fragment of IgE Receptor Ia (FCER1A))

Binding Specificity: AA 42-103

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This Fc epsilon RI/FCER1A antibody is un-conjugated

Application: Flow Cytometry (FACS), Western Blotting (WB), ELISA

Purpose: FCER1A Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human FCER1A (AA:42-103) expressed in E. Coli.

Clone: 1F2A9

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-Fc epsilon RI/FCER1A antibody (ABIN1724785)

Zhou, Zhou, Lin, Wang, Peng, Li, Li: "Association of polymorphisms in the promoter region of FCER1A gene with atopic dermatitis, chronic uticaria, asthma, and serum immunoglobulin E levels in a Han Chinese population." in: Human immunology, Vol. 73, Issue 3, pp. 301-5, (2012) (PubMed).

Potaczek, Nastalek, Wojas-Pelc, Okumura, Undas, Nishiyama: "Naturally occurring FCER1A N222K mutation - its ethnicity-dependent distribution and a role in atopic dermatitis." in: Molecular immunology, Vol. 48, Issue 8, pp. 979-80, (2011) (PubMed).

Target Details for Fc epsilon RI/FCER1A

Target: Fc epsilon RI/FCER1A (FCER1A) (Fc Fragment of IgE Receptor Ia (FCER1A))

Alternative Name: FCER1A (FCER1A Products)

Background: The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit.

Molecular Weight: 29.6 kDa

Pathways: Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process