CD33 antibody (AA 15-237)

Catalog No. ABIN1724813

The Mouse Monoclonal anti-CD33 antibody has been validated for FACS, WB, ELISA and IHC. It is suitable to detect CD33 in samples from Human. There are 2+ publications available.

Quick Overview for CD33 antibody (AA 15-237) (ABIN1724813)

Target: CD33

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD33 antibody is un-conjugated

Application: Flow Cytometry (FACS), Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Clone: 2C6B7

Product Details anti-CD33 Antibody

Binding Specificity: AA 15-237

Purpose: CD33 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human CD33 (AA: 15-237) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-CD33 antibody (ABIN1724813)

Deng, Liu, Wang, Tang, Ren, Xu, Ma, Wang, Zhuang, Wang, Chen: "The prevalence of CD33 and MS4A6A variant in Chinese Han population with Alzheimer's disease." in: Human genetics, Vol. 131, Issue 7, pp. 1245-9, (2012) (PubMed).

Schubert, Kellner, Stein, Kügler, Schwenkert, Saul, Mentz, Singer, Stockmeyer, Hillen, Mackensen, Fey: "A single-chain triplebody with specificity for CD19 and CD33 mediates effective lysis of mixed lineage leukemia cells by dual targeting." in: mAbs, Vol. 3, Issue 1, pp. 21-30, (2011) (PubMed).

Target Details for CD33

Target: CD33

Alternative Name: CD33

Background: The protein encoded by this gene belongs to putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro) and CD33 plays potential key roles in the pathogenesis of Alzheimer's disease (AD)

Molecular Weight: 39.8 kDa

Gene ID: 945

UniProt: P20138