CD166 antibody (AA 48-216)

Catalog No. ABIN1724851

Product Details anti-CD166 Antibody

Target: CD166 (ALCAM) (Activated Leukocyte Cell Adhesion Molecule (ALCAM))

Binding Specificity: AA 48-216

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD166 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Purpose: ALCAM Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human ALCAM (AA: 48-216) expressed in E. Coli.

Clone: 8E12C7

Isotype: IgG2a

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-CD166 antibody (ABIN1724851)

Rauch, Rosenkranz, Böhm, Meyer-Kirchrath, Hohlfeld, Schrör, Rauch: "Cholesterol induces apoptosis-associated loss of the activated leukocyte cell adhesion molecule (ALCAM) in human monocytes." in: Vascular pharmacology, Vol. 54, Issue 3-6, pp. 93-9, (2011) (PubMed).

Liang, Huang, Jia, Wang: "Activated leukocyte cell adhesion molecule expression is up-regulated in the development of endometrioid carcinoma." in: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, Vol. 21, Issue 3, pp. 523-8, (2011) (PubMed).

Target Details for CD166

Target: CD166 (ALCAM) (Activated Leukocyte Cell Adhesion Molecule (ALCAM))

Alternative Name: ALCAM (ALCAM Products)

Background: This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found.

Molecular Weight: 65.1 kDa

Gene ID: 214

UniProt: Q13740