Decorin antibody (AA 263-324)

Catalog No. ABIN1724881

This Mouse Monoclonal antibody specifically detects Decorin in ELISA and FACS. It exhibits reactivity toward Human and has been mentioned in 2+ publications.

Quick Overview for Decorin antibody (AA 263-324) (ABIN1724881)

Target: Decorin (DCN)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Decorin antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS)

Clone: 5E8E7

Product Details anti-Decorin Antibody

Binding Specificity: AA 263-324

Purpose: DCN Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human DCN (AA: 263-324) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-Decorin antibody (ABIN1724881)

Buraschi, Neill, Owens, Iniguez, Purkins, Vadigepalli, Evans, Schaefer, Peiper, Wang, Iozzo: "Decorin protein core affects the global gene expression profile of the tumor microenvironment in a triple-negative orthotopic breast carcinoma xenograft model." in: PLoS ONE, Vol. 7, Issue 9, pp. e45559, (2012) (PubMed).

Adam, Saller, Ströbl, Hennebold, Dissen, Ojeda, Stouffer, Berg, Berg, Mayerhofer: "Decorin is a part of the ovarian extracellular matrix in primates and may act as a signaling molecule." in: Human reproduction (Oxford, England), Vol. 27, Issue 11, pp. 3249-58, (2012) (PubMed).

Target Details for Decorin

Target: Decorin (DCN)

Alternative Name: DCN

Background: The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to biglycan protein. The encoded protein and biglycan are thought to be the result of a gene duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. It contains one attached glycosaminoglycan chain. This protein is capable of suppressing the growth of various tumor cell lines. There are multiple alternatively spliced transcript variants known for this gene. This gene is a candidate gene for Marfan syndrome.

Molecular Weight: 39.7 kDa

Gene ID: 1634

UniProt: P07585

Pathways: Glycosaminoglycan Metabolic Process