PTP4A2 antibody (AA 58-162)

Catalog No. ABIN1724901

Product Details anti-PTP4A2 Antibody

Target: PTP4A2 (Protein tyrosine Phosphatase Type IVA, Member 2 (PTP4A2))

Binding Specificity: AA 58-162

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PTP4A2 antibody is un-conjugated

Application: ELISA

Purpose: PTP4A2 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human PTP4A2 (AA: 58-162) expressed in E. Coli.

Clone: 5B6F4

Isotype: IgG2b

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-PTP4A2 antibody (ABIN1724901)

Hardy, Wong, Muller, Park, Tremblay: "Overexpression of the protein tyrosine phosphatase PRL-2 correlates with breast tumor formation and progression." in: Cancer research, Vol. 70, Issue 21, pp. 8959-67, (2010) (PubMed).

Akiyama, Dhavan, Yi: "PRL-2 increases Epo and IL-3 responses in hematopoietic cells." in: Blood cells, molecules & diseases, Vol. 44, Issue 4, pp. 209-14, (2010) (PubMed).

Target Details for PTP4A2

Target: PTP4A2 (Protein tyrosine Phosphatase Type IVA, Member 2 (PTP4A2))

Alternative Name: PTP4A2 (PTP4A2 Products)

Background:

Description: The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17.

Aliases: HH13, OV-1, PRL2, HH7-2, PRL-2, PTP4A, HU-PP-1, PTPCAAX2, ptp-IV1a, ptp-IV1b

Molecular Weight: 19.1kDa

Gene ID: 8073

HGNC: 8073

UniProt: Q12974