SOX10 antibody (AA 147-252)

Catalog No. ABIN1724912

Product Details anti-SOX10 Antibody

Target: SOX10 (SRY (Sex Determining Region Y)-Box 10 (SOX10))

Binding Specificity: AA 147-252

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SOX10 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Purpose: SOX10 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human SOX10 (AA: 147-252) expressed in E. Coli.

Clone: 2E7E8

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-SOX10 antibody (ABIN1724912)

Shin, Vincent, Cuda, Xu, Kang, Kim, Taube: "Sox10 is expressed in primary melanocytic neoplasms of various histologies but not in fibrohistiocytic proliferations and histiocytoses." in: Journal of the American Academy of Dermatology, Vol. 67, Issue 4, pp. 717-26, (2012) (PubMed).

Bannykh, Stolt, Kim, Perry, Wegner: "Oligodendroglial-specific transcriptional factor SOX10 is ubiquitously expressed in human gliomas." in: Journal of neuro-oncology, Vol. 76, Issue 2, pp. 115-27, (2006) (PubMed).

Target Details for SOX10

Target: SOX10 (SRY (Sex Determining Region Y)-Box 10 (SOX10))

Alternative Name: SOX10 (SOX10 Products)

Background: This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease.

Molecular Weight: 49.9 kDa

Gene ID: 6663

UniProt: P56693

Pathways: Chromatin Binding