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SOX10 antibody (Middle Region)

SOX10 Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2777864
  • Target See all SOX10 Antibodies
    SOX10 (SRY (Sex Determining Region Y)-Box 10 (SOX10))
    Binding Specificity
    • 34
    • 16
    • 10
    • 6
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
    Host
    • 67
    • 38
    • 2
    Rabbit
    Clonality
    • 54
    • 53
    Polyclonal
    Conjugate
    • 49
    • 9
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This SOX10 antibody is un-conjugated
    Application
    • 82
    • 37
    • 30
    • 28
    • 27
    • 18
    • 15
    • 14
    • 12
    • 10
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequence
    PGGEAEQGGT AAIQAHYKSA HLDHRHPGEG SPMSDGNPEH PSGQSHGPPT
    Predicted Reactivity
    Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 86%
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human SOX10
    Top Product
    Discover our top product SOX10 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 466 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Wilson, Olm-Shipman, Acevedo, Palaniyandi, Hall, Kosa, Stumpff, Smith, Pitstick, Liao, Bjork, Czirok, Saadi: "SPECC1L deficiency results in increased adherens junction stability and reduced cranial neural crest cell delamination." in: Scientific reports, Vol. 6, pp. 17735, (2016) (PubMed).

  • Target
    SOX10 (SRY (Sex Determining Region Y)-Box 10 (SOX10))
    Alternative Name
    SOX10 (SOX10 Products)
    Synonyms
    DOM antibody, PCWH antibody, WS2E antibody, WS4 antibody, WS4C antibody, SOX-10 antibody, SOX10 antibody, dom antibody, ws4 antibody, Dom antibody, Sox21 antibody, SOX9 antibody, cls/sox10 antibody, zgc:100757 antibody, SRY-box 10 antibody, SRY box 10 antibody, SRY-box 10 L homeolog antibody, SRY (sex determining region Y)-box 10 antibody, SOX10 antibody, Sox10 antibody, sox10.L antibody, sox10 antibody
    Background
    SOX10 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. This protein may act as a transcriptional activator after forming a protein complex with other proteins. It acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease.
    Alias Symbols: DOM, MGC15649, WS2E, WS4, PCWH, WS4C
    Protein Interaction Partner: UBC, CDK6, EXOC5, NMI, EPAS1, POU3F2, UTF1, PAX3, UBE2I, OLIG2, HHEX, PAX6, ALX4, PRRX2, SUMO2, POU3F3, SUMO3, SOX10, SUMO1, TCF12, MEOX1, DLX5, HIVEP1, SP1, PRRX1, JUN, POU5F1, HOXC4, HOXA3, EGR2, CEBPA,
    Protein Size: 466
    Molecular Weight
    50 kDa
    Gene ID
    6663
    NCBI Accession
    NM_006941, NP_008872
    UniProt
    P56693
    Pathways
    Chromatin Binding
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