Amyloid Fibrils antibody

Details for Product No. ABIN1731752
Antigen
Reactivity
Human, Mouse (Murine), Rat (Rattus)
5
1
1
Host
Rabbit
5
Clonality
Polyclonal
Application
Dot Blot (DB), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
5
5
5
4
2
1
1
Options
Immunogen Fibrils prepared from human Abeta42 peptide
Isotype IgG
Specificity Reacts withepitopes common to many human amyloid fibrils and fibrillar oligomers but not prefibrillar oligomers or natively folded proteins. Predicted to recognize mouse and rat based on sequence homology.
Purification Purified
Antigen
Background Amyloid monomeric proteins can oligomerize into destructive amyloid fibrils. Amyloidogenic conformations of non-disease related proteins can be created by partial protein misfolding or denaturation. Many degenerative diseases are known to be related to the accumulation of misfolded proteins as amyloid fibers.
Application Notes Working dilution: Optimal dilutions should be determined by the end user.
The following are guidelines only:
WB1 -2 μg/mL DB0.5 - 1 μg/mL IHC1 -5 μg/mL ELISA1 - 10 μg/mL with amyloid fibril-containing samples on the solid phase.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS pH 7.0, 50 % glycerol
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Dilute in PBS or medium which is identical to that used in the assay system.
Storage -20 °C
Storage Comment This product is stable for at least 1 year at -20°C. Freeze in multiple aliquots to avoid repeated freeze-thaw cycles.