PARK7/DJ1 antibody (N-Term)

Catalog No. ABIN1737863

The Rabbit Polyclonal anti-PARK7/DJ1 antibody is suitable to detect PARK7/DJ1 in samples from Human and Mouse. It has been validated for WB.

Quick Overview for PARK7/DJ1 antibody (N-Term) (ABIN1737863)

Target: PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PARK7/DJ1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PARK7/DJ1 Antibody

Binding Specificity: AA 167-189, N-Term

Specificity: Reacts with human and mouse PARK7. Sequence homology to mouse and rat DJ-1 is 82 % .

Purification: Purified

Immunogen: Synthetic peptide corresponding to amino acids 167-189 (AIVEALNGKEVAAQVKAPLVLKD) of human PARK7 conjugated to KLH at the N-terminus.

Isotype: IgG

Application Details

Application Notes: Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
WB1:500

Positive control: HEK293 cell lysate or mouse brain tissue lysate

Restrictions: For Research Use only

Handling

Buffer: PBS, pH 7.4,

Handling Advice: Dilute in PBS or medium which is identical to that used in the assay system.

Storage: 4 °C/-20 °C

Storage Comment: Short term storage at+4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 months from date of receipt.

Expiry Date: 6 months

Target Details for PARK7/DJ1

Target: PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))

Alternative Name: Park7

Background: Park7/DJ-1 is one of several genes thought to cause autosomal-recessive early-onset parkinsonism. Protects cells against oxidative stress and cell death. Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death.

Protein DJ-1 Oncogene DJ1 Parkinson disease protein 7 Gene name: PARK7

Gene ID: 11315

UniProt: Q99497

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Proton Transport