IDO1 antibody (AA 78-184)

Catalog No. ABIN180889

This Mouse Monoclonal antibody specifically detects IDO1 in WB and IHC (fro). It exhibits reactivity toward Human and Mouse.

Quick Overview for IDO1 antibody (AA 78-184) (ABIN180889)

Target: IDO1 (Indoleamine 2,3-Dioxygenase 1 (IDO1))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This IDO1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 10-01-14

Product Details anti-IDO1 Antibody

Binding Specificity: AA 78-184

Specificity: This Monoclonal antibody 10.1 recognizes Indoleamine-pyrrole 2,3-dioxygenase (IDO), an enzyme responsible for the catabolism of Tryptophan to N-Formlkynurenine and Kynurenine. In Western Blotting, it recognizes a 45 kDa band in IFN-gamma treated Human cell lines. This antibody recognizes a slightly lower Molecular Weight band in Mouse IDO compared to its Human counterpart.

Characteristics: Synonyms: IDO1, IDO, INDO, Indoleamine 2, 3-dioxygenase 1, EC=1.13.11.52, 3-dioxygenase,Indoleamine-pyrrole 2

Purification: Purified

Immunogen: Peptide corresponding to amino acids 78-184 of human IDO fused to GST

Isotype: IgG3

Application Details

Application Notes: Western Blot. Immunohistochemistry on frozen sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS, 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for IDO1

Target: IDO1 (Indoleamine 2,3-Dioxygenase 1 (IDO1))

Alternative Name: IDO1 / INDO

Background: With the exception of tryptophan oxidase in hepatocytes, IDO is the only enzyme that degrades the amino acid tryptophan to kynurenine. Chlamydial pathogens require tryptophan for growth. IDO can lower available tryptophan in target cells leading to conversion of the pathogen to persistant forms, with significance in the progression to chronic infection with its associated pathological effects.Synonyms: 3-dioxygenase, 3-dioxygenase 1, EC=1.13.11.52, IDO, IDO1, INDO, Indoleamine 2, Indoleamine-pyrrole 2

Gene ID: 3620

UniProt: P14902

Pathways: Activated T Cell Proliferation