Complement C8 antibody

Catalog No. ABIN181126

This Mouse Monoclonal antibody specifically detects Complement C8 in FACS, WB, EIA and IHC (fro). It exhibits reactivity toward Human.

Quick Overview for Complement C8 antibody (ABIN181126)

Target: Complement C8 (C8)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Complement C8 antibody is un-conjugated

Application: Flow Cytometry (FACS), Western Blotting (WB), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 056B-373

Product Details anti-Complement C8 Antibody

Specificity: This antibody recognizes complement component 8 (C8), a 151 kDa member of the complement C6/C7/C8/C9 family, present in blood serum.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Characteristics: Synonyms: Complement component C8, Complement 8

Purification: Affinity Chromatography on Protein A

Immunogen: Purified Human C8. Genename: C8

Isotype: IgG1

Application Details

Application Notes: ELISA. Western Blot. Flow Cytometry. Immunohistochemistry on Frozen Sections. Recommended Positive Control: Kidney from post streptoccal glomerulonephritis patients.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Borate buffered saline pH 8.2-8.4 containing 0.02 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for Complement C8

Target: Complement C8 (C8)

Alternative Name: Complement C8

Background: C8 is a terminal component of the complement system, part of both the complement membrane attack complex (MAC), and important to MAC assembly. C8 binds to the C5b-7 complex, anchored to the membrane, creating C5b-8. C5b-8 binds C9 and catalyses the polymerization of C9 Molecules to form C5-b9 (MAC). C8 is thought to contain lipid binding sites, facilitating the insertion of MAC into the membrane. Defects in the alpha chain of C8 can result in complement C8 deficiency type I. Furthermore, C8 deficiencies can cause recurring bacterial infections, in particular from Neisseria meningitides.Synonyms: Complement 8, Complement component C8

Gene ID: 732

UniProt: P07358