CD300a antibody (PE)

Catalog No. ABIN1819155

Product Details anti-CD300a Antibody (PE)

Target: CD300a (CD300A)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD300a antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Specificity: Recognizes human CD300a, otherwise known as IRp60 (inhibitory receptor protein 60), a 60kD transmembrane glycoprotein expressed by natural killer cells (NK), T and B cell subsets, monocytes, neutrophils, macrophages, granulocytes, dendritic cells (DC) and mast cells. Studies have shown that the cross-linking of CD300a on NK results in a down-regulation of their cytolytic activity, whilst cross-linking of CD300a on mast cells, inhibits IgE-induced degranulation and SCF-mediated survival. Furthermore, cross-linking of CD300a on the surface of eosinophils has been shown to significantly inhibit their survival, chemotaxis and activation in response to certain inflammatory cytokines, whilst eosinophil-derived MBP (major basic protein) and EDN (neurotoxin), can down-regulate CD300a expression on mast cells in vitro.

Purification: Protein G purified

Immunogen: Polyclonal population of NK cells.

Type of Immunogen: Cells

Clone: P192

Isotype: IgG2a

Application Details

Application Notes: Approved: Flo

Usage: The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Reconstitution: Reconstitute with 1 mL distilled water.

Concentration: Lot specific

Buffer: PBS, 0.09 % sodium azide, 1 % BSA, 5 % sucrose

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Do not freeze. Protect from light.

Storage: 4 °C

Storage Comment: Store at 4°C. Do not freeze. Protect from light.

Target Details for CD300a

Target: CD300a (CD300A)

Alternative Name: CD300A (CD300A Products)

Background: Name/Gene ID: CD300A

Synonyms: CD300A, CD300a antigen, CD300a molecule, CMRF35-like molecule 8, CMRF35-H, CMRF35-H9, CLM-8, CMRF35H9, IGSF12, Inhibitory receptor protein 60, IRC2, IRC1, NK inhibitory receptor, CMRF-35-H9, CMRF-35H, CMRF35H, IRC1a, IRp60, Leukocyte membrane antigen

Gene ID: 11314

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process