CCR7 antibody (AA 2-22)

Catalog No. ABIN1819309

This Goat Polyclonal antibody specifically detects CCR7 in WB, FACS, ELISA, IHC, IHC (p) and Func. It exhibits reactivity toward Human and Mouse.

Quick Overview for CCR7 antibody (AA 2-22) (ABIN1819309)

Target: CCR7 (Chemokine (C-C Motif) Receptor 7 (CCR7))

Reactivity: Human, Mouse

Host: Goat

Clonality: Polyclonal

Conjugate: This CCR7 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), ELISA, Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Functional Studies (Func)

Product Details anti-CCR7 Antibody

Binding Specificity: AA 2-22

Specificity: Recognizes mouse C-C chemokine receptor type 7, also known as CD197, CCR7, Epstein-Barr virus-induced G-protein coupled receptor 1 or MIP-3 beta receptor. CD197 is a 378 amino acid ~43 kD multi pass type III transmembrane glycoprotein and member of the G-protein coupled receptor 1 family. CD197 is expressed by various lymphoid tissues, activated B and T cells, naive T cells, NK cells and dendritic cells (DCs), which acts a high-affinity receptor for the chemokines MIP-3beta (CCL19) and CCL21. Ligand binding of CD197 plays a vital role in the homing of naive T cells and antigen-loaded DCs into secondary organs. Expression of CD197 is strongly up-regulated in B cells infected with Epstein-Barr virus (EBV) and T cells infected with herpesvirus 6 or 7. Can be used in research studies to distinguish between central memory and effector memory T cells and is reported as suitable for use in immunocytochemistry.

Purification: Affinity purified

Immunogen: Synthetic peptide DPGKPRKNVLVVALLVIFQVC corresponding to amino acids 2-22 of mouse CD197. Percent identity by BLAST analysis: Mouse (100%), Rat, Hamster, Bovine (90%), Human, Chimpanzee, Gorilla, Gibbon, Monkey, Marmoset (86%), Orangutan, Galago, Ferret, Dog, Cat, Horse (81%).

Type of Immunogen: Synthetic peptide

Isotype: IgG

Application Details

Application Notes: Approved: ELISA (1:100000), Flo (1:10), Func, IHC, IHC-P (1:250), WB (1:1000)

Comment:

Target Species of Antibody: Mouse

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS, 0.1 % sodium azide, 0.1 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze-thaw cycles.

Target Details for CCR7

Target: CCR7 (Chemokine (C-C Motif) Receptor 7 (CCR7))

Alternative Name: CCR7

Background: Name/Gene ID: CCR7
Subfamily: Chemokine
Family: GPCR

Synonyms: CCR7, BLR2, Chemokine (C-C) receptor 7, CD197, C-C CKR-7, CMKBR7, CC chemokine receptor 7, CCR-7, CD197 antigen, CDw197, EBI1, EVI1, MIP-3 beta receptor, C-c chemokine receptor 7, C-C chemokine receptor type 7, CC-CKR-7, Chemokine c-c motif receptor 7

Gene ID: 1236

Pathways: Regulation of Actin Filament Polymerization, Positive Regulation of Immune Effector Process