CD177 antibody

Catalog No. ABIN1837719

Product Details anti-CD177 Antibody

Target: CD177 (CD177 Molecule (CD177))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD177 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP)

Specificity: Cd177 (NP1), a glycosyl phosphatidylinositol (GPI) linked N glycosylated cell surface glycoprotein, was first described in a case of neonatal alloimmune neutropenia and analyses showed cell surface expression of a 60 kD protein, 14 kD greater than the predicted size, probably due to the presence of 3 potential N glycosylation sites. Immunohistochemistry demonstrated expression in bone marrow early erythroblasts, megakaryocytes, promyelocytes, and myelocytes. The neutrophil NB1 antigen (CD177) is expressed by 97 % of the Caucasian population. Antibodies against NB1 can be involved in neonatal alloimmune neutropenia (NAN).

Purification: Purified

Immunogen: Human granulocytes.

Type of Immunogen: Cells

Clone: MEM-166

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS,  pH 7.4, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 4°C.

Target Details for CD177

Target: CD177 (CD177 Molecule (CD177))

Alternative Name: CD177 (CD177 Products)

Background: Name/Gene ID: CD177

Synonyms: CD177, CD177 Molecule, CD177 antigen, Cell surface receptor, HNA-2a, HNA2A, NB1, PRV-1, Polycythemia rubra vera 1, PRV1, NB1 glycoprotein, NB1 GP

Gene ID: 57126

UniProt: Q8N6Q3