B-Cell Linker antibody (AA 171-356)

Catalog No. ABIN1838325

This anti-B-Cell Linker antibody is a Rabbit Polyclonal antibody detecting B-Cell Linker in WB. Suitable for Human.

Quick Overview for B-Cell Linker antibody (AA 171-356) (ABIN1838325)

Target: B-Cell Linker (BLNK)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This B-Cell Linker antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-B-Cell Linker Antibody

Binding Specificity: AA 171-356

Specificity: BLNK (B cell linker protein) is an adaptor molecule that plays key role in B cell activation initiated by cross-linking the B cell receptor (BCR). This activation leads to an increase in the tyrosine phosphorylation of a number of proteins due to activation of nonreceptor protein tyrosine kinases (PTK) including Syk, which is responsible for the tyrosine phosphorylation of BLNK. BLNK is cytosolic protein identified as two phosphoproteins migrating at 68 and 70 kD in SDS/PAGE (alternatively spliced forms of human BLNK). Mapping of the tyrosine residues in BLNK reveal three tyrosines that bind PLC-gamma2, and two tyrosines that bind the Tec family kinase Btk, the Vav nucleotide exchange factor and the adaptor Nck.

Purification: Purified

Immunogen: A fusion protein representing amino acids 171-356 of human BLNK.

Type of Immunogen: Fusion protein

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS,  pH 7.4, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.

Target Details for B-Cell Linker

Target: B-Cell Linker (BLNK)

Alternative Name: BLNK

Background: Name/Gene ID: BLNK
Family: Signal Transduction

Synonyms: BLNK, AGM4, BLNK-S, B-cell activation, B-cell linker protein, B cell linker protein, Bca, Cytoplasmic adapter protein, LY57, SLP-65, SLP65, B-cell linker, BASH

Gene ID: 29760

UniProt: Q8WV28

Pathways: BCR Signaling