ABCA1 antibody

Catalog No. ABIN187475

The Mouse Monoclonal anti-ABCA1 antibody has been validated for WB, IP, IHC (fro) and EIA. It is suitable to detect ABCA1 in samples from Human.

Quick Overview for ABCA1 antibody (ABIN187475)

Target: ABCA1 (ATP-Binding Cassette, Sub-Family A (ABC1), Member 1 (ABCA1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ABCA1 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Clone: AB1-G6

Product Details anti-ABCA1 Antibody

Specificity: Mutations in the ABCA1 gene (ATP-binding cassette transporter 1) are associated with Tangier disease (TD). TD is an autosomal recessive disorder resulting from an absence of plasma HDL, cholesterol ester depositing in the reticulo-endothelial system and disorders in cellular lipid trafficking. It is expressed on the plasma membrane and the Golgi complex and is regulated by cholesterol flux. Regulation of the cholesterol flux between HDL and macrophages is competitive between ABCA1 and SR-BI. Species Human. Other species not tested.

Immunogen: Peptide corresponding to amino acids 1800-2260.

Isotype: IgG1

Application Details

Application Notes: Immunohistochemistry Western blot ELISA Immunoprecipitation The optimal dilution for a specific application should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 100 µg of antibody at 1 mg/mL in PBS, pH 7.4, with 0.5% sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for ABCA1

Target: ABCA1 (ATP-Binding Cassette, Sub-Family A (ABC1), Member 1 (ABCA1))

Alternative Name: ABCA1

Pathways: Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process, Regulation of Lipid Metabolism by PPARalpha, Lipid Metabolism