eIF4EBP2 antibody (C-Term)

Catalog No. ABIN1881292

This Rabbit Polyclonal antibody specifically detects eIF4EBP2 in WB. It exhibits reactivity toward Human. It has been mentioned in 3+ publications

Quick Overview for eIF4EBP2 antibody (C-Term) (ABIN1881292)

Target: eIF4EBP2 (EIF4EBP2) (Eukaryotic Translation Initiation Factor 4E Binding Protein 2 (EIF4EBP2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This eIF4EBP2 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB41859

Product Details anti-eIF4EBP2 Antibody

Binding Specificity: AA 87-115, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This EIF4EBP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 87-115 amino acids from the C-terminal region of human EIF4EBP2.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-eIF4EBP2 antibody (ABIN1881292)

Bidinosti, Martineau, Frank, Sonenberg: "Repair of isoaspartate formation modulates the interaction of deamidated 4E-BP2 with mTORC1 in brain." in: The Journal of biological chemistry, Vol. 285, Issue 25, pp. 19402-8, (2010) (PubMed).

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, (2010) (PubMed).

Gingras, Sonenberg: "Adenovirus infection inactivates the translational inhibitors 4E-BP1 and 4E-BP2." in: Virology, Vol. 237, Issue 1, pp. 182-6, (1997) (PubMed).

Target Details for eIF4EBP2

Target: eIF4EBP2 (EIF4EBP2) (Eukaryotic Translation Initiation Factor 4E Binding Protein 2 (EIF4EBP2))

Alternative Name: EIF4EBP2

Background: This gene encodes a member of the eukaryotic translation initiation factor 4E binding protein family. The gene products of this family bind eIF4E and inhibit translation initiation. However, insulin and other growth factors can release this inhibition via a phosphorylation-dependent disruption of their binding to eIF4E. Regulation of protein production through these gene products have been implicated in cell proliferation, cell differentiation and viral infection.

Molecular Weight: 12939

NCBI Accession: NP_004087

UniProt: Q13542