FAP antibody (N-Term)

Catalog No. ABIN1881337

This Rabbit Polyclonal antibody specifically detects FAP in WB and IHC (p). It exhibits reactivity toward Mouse and has been mentioned in 3+ publications.

Quick Overview for FAP antibody (N-Term) (ABIN1881337)

Target: FAP (Fibroblast Activation Protein, alpha (FAP))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FAP antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB40867

Product Details anti-FAP Antibody

Binding Specificity: AA 15-41, N-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Mouse Fap antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-41 amino acids from the N-terminal region of mouse Fap.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000. WB: 1:500. IHC-P: 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-FAP antibody (ABIN1881337)

Wen, Wang, Ma, Li, Zhou, Mu, Leng, Shi, Li, Wei: "Immunotherapy targeting fibroblast activation protein inhibits tumor growth and increases survival in a murine colon cancer model." in: Cancer science, Vol. 101, Issue 11, pp. 2325-32, (2010) (PubMed).

Santos, Jung, Aziz, Kissil, Puré: "Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice." in: The Journal of clinical investigation, Vol. 119, Issue 12, pp. 3613-25, (2009) (PubMed).

Kennedy, Dong, Chen, Chen: "Elevation of seprase expression and promotion of an invasive phenotype by collagenous matrices in ovarian tumor cells." in: International journal of cancer. Journal international du cancer, Vol. 124, Issue 1, pp. 27-35, (2008) (PubMed).

Target Details for FAP

Target: FAP (Fibroblast Activation Protein, alpha (FAP))

Alternative Name: Fap

Background: In association with DPP4 is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM (By similarity). May have a role in tissue remodeling during development and wound healing, and contribute to invasiveness in malignant cancers.

Molecular Weight: 87945

NCBI Accession: NP_032012

UniProt: P97321

Pathways: Tube Formation