FAP antibody (AA 525-624)

Catalog No. ABIN560844

Cited in 4+ publications. The Mouse Monoclonal anti-FAP antibody (Clone 1E5) (ABIN560844) specifically detects FAP in WB, ELISA and IP. The antibody is reactive with Human samples.

Quick Overview for FAP antibody (AA 525-624) (ABIN560844)

Target: FAP (Fibroblast Activation Protein, alpha (FAP))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FAP antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Clone: 1E5

Product Details anti-FAP Antibody

Binding Specificity: AA 525-624

Purpose: Mouse monoclonal antibody raised against a partial recombinant FAP.

Sequence: PPQFDRSKKY PLLIQVYGGP CSQSVRSVFA VNWISYLASK EGMVIALVDG RGTAFQGDKL LYAVYRKLGV YEVEDQITAV RKFIEMGFID EKRIAIWGWS

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: FAP (AAH26250, 525 a.a. ~ 624 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-FAP antibody (ABIN560844)

Bohonowych, Hance, Nolan, Defee, Parsons, Isaacs: "Extracellular Hsp90 mediates an NF-?B dependent inflammatory stromal program: implications for the prostate tumor microenvironment." in: The Prostate, Vol. 74, Issue 4, pp. 395-407, (2014) (PubMed).

Chung, Hsu, Chu, Lin, Jiaang, Chen, Chen: "Fibroblast activation protein (FAP) is essential for the migration of bone marrow mesenchymal stem cells through RhoA activation." in: PLoS ONE, Vol. 9, Issue 2, pp. e88772, (2014) (PubMed).

Denys, Derycke, Hendrix, Westbroek, Gheldof, Narine, Pauwels, Gespach, Bracke, De Wever: "Differential impact of TGF-beta and EGF on fibroblast differentiation and invasion reciprocally promotes colon cancer cell invasion." in: Cancer letters, Vol. 266, Issue 2, pp. 263-74, (2008) (PubMed).

Wang, Yao, Nadvi, Osborne, McCaughan, Gorrell: "Fibroblast activation protein and chronic liver disease." in: Frontiers in bioscience : a journal and virtual library, Vol. 13, pp. 3168-80, (2007) (PubMed).

Target Details for FAP

Target: FAP (Fibroblast Activation Protein, alpha (FAP))

Alternative Name: FAP

Background: Full Gene Name: fibroblast activation protein, alpha
Synonyms: DKFZp686G13158,DPPIV,FAPA

Gene ID: 2191

Pathways: Tube Formation