MMP14 antibody (C-Term)

Catalog No. ABIN1881546

This anti-MMP14 antibody is a Rabbit Polyclonal antibody detecting MMP14 in WB. Suitable for Human. This Primary Antibody has been cited in 1 publication.

Quick Overview for MMP14 antibody (C-Term) (ABIN1881546)

Target: MMP14 (Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MMP14 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB41662

Product Details anti-MMP14 Antibody

Binding Specificity: AA 495-523, C-Term

Predicted Reactivity: M, Pig, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This MMP14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 495-523 amino acids from the C-terminal region of human MMP14.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-MMP14 antibody (ABIN1881546)

Sakr, Takino, Domoto, Nakano, Wong, Sasaki, Nakanuma, Sato: "GI24 enhances tumor invasiveness by regulating cell surface membrane-type 1 matrix metalloproteinase." in: Cancer science, Vol. 101, Issue 11, pp. 2368-74, (2010) (PubMed).

Target Details for MMP14

Target: MMP14 (Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14))

Alternative Name: MMP14

Background: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.

Molecular Weight: 65894

NCBI Accession: NP_004986

UniProt: P50281

Pathways: Autophagy