Neurogenin 1 antibody (AA 112-138)

Catalog No. ABIN1881577

This Rabbit Polyclonal antibody specifically detects Neurogenin 1 in WB. It exhibits reactivity toward Zebrafish (Danio rerio) and has been mentioned in 3+ publications.

Quick Overview for Neurogenin 1 antibody (AA 112-138) (ABIN1881577)

Target: Neurogenin 1 (NEUROG1)

Reactivity: Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Neurogenin 1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Neurogenin 1 Antibody

Binding Specificity: AA 112-138

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This DANRE neurog1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 112-138 amino acids from the Central region of DANRE neurog1.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-Neurogenin 1 antibody (ABIN1881577)

Korzh, Sleptsova, Liao, He, Gong: "Expression of zebrafish bHLH genes ngn1 and nrd defines distinct stages of neural differentiation." in: Developmental dynamics : an official publication of the American Association of Anatomists, Vol. 213, Issue 1, pp. 92-104, (1999) (PubMed).

Kim, Bae, Yamanaka, Yamashita, Shimizu, Fujii, Park, Yeo, Huh, Hibi, Hirano: "Overexpression of neurogenin induces ectopic expression of HuC in zebrafish." in: Neuroscience letters, Vol. 239, Issue 2-3, pp. 113-6, (1998) (PubMed).

Blader, Fischer, Gradwohl, Guillemot, Strähle: "The activity of neurogenin1 is controlled by local cues in the zebrafish embryo." in: Development (Cambridge, England), Vol. 124, Issue 22, pp. 4557-69, (1998) (PubMed).

Target Details for Neurogenin 1

Target: Neurogenin 1 (NEUROG1)

Alternative Name: neurog1

Background: Transcriptional regulator. Activates transcription by binding to the E box-containing promoter (By similarity). Mediates neuronal differentiation. Required for the development of Rohon-Beard spinal sensory neurons and dorsal root ganglion neurons, but not for primary motoneurons or autonomic neurons. Required for development of all cranial ganglia but not associated glial cells. Regulates epiphysial neurogenesis, acting partially redundantly with ascl1a and downstream of flh. Required for the development of basal forebrain dopaminergic neurons, involved in the specification of dopaminergic progenitor cells. May be involved in maintaining rhombomere boundaries in the hindbrain.

Molecular Weight: 22911

NCBI Accession: NP_571116

UniProt: O42606