PTF1A antibody (N-Term)

Catalog No. ABIN1881703

Product Details anti-PTF1A Antibody

Target: PTF1A (Pancreas Specific Transcription Factor, 1a (PTF1A))

Binding Specificity: AA 12-43, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTF1A antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Predicted Reactivity: Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Ptf1a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-43 amino acids from the N-terminal region of human Ptf1a.

Clone: RB10418

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-PTF1A antibody (ABIN1881703)

Yamada, Terao, Terashima, Fujiyama, Kawaguchi, Nabeshima, Hoshino: "Origin of climbing fiber neurons and their developmental dependence on Ptf1a." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, Issue 41, pp. 10924-34, (2007) (PubMed).

Target Details for PTF1A

Target: PTF1A (Pancreas Specific Transcription Factor, 1a (PTF1A))

Alternative Name: Ptf1a (PTF1A Products)

Synonyms: PTF1A antibody, PTF1 antibody, si:zc142h2.2 antibody, zgc:112216 antibody, Ptf1a/p48 antibody, XPtf1a antibody, PTF1-p48 antibody, bHLHa29 antibody, PTF1p48 antibody, pancreas specific transcription factor, 1a antibody, PTF1A antibody, ptf1a antibody, Ptf1a antibody

Background: Ptf1a is a component of the pancreas transcription factor 1 complex (PTF1) and is known to have a role in mammalian pancreatic development. The protein plays a role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. This protein is thought to be involved in the maintenance of exocrine pancreas-specific gene expression including elastase 1 and amylase. Mutations in the Ptf1a gene cause cerebellar agenesis and loss of expression is seen in ductal type pancreas cancers.

Molecular Weight: 34970

NCBI Accession: NP_835455

UniProt: Q7RTS3

Pathways: Retinoic Acid Receptor Signaling Pathway