CASK antibody (AA 589-616)

Catalog No. ABIN1881710

The Rabbit Polyclonal anti-CASK antibody has been validated for WB. It is suitable to detect CASK in samples from Rat. There are 5+ publications available.

Quick Overview for CASK antibody (AA 589-616) (ABIN1881710)

Target: CASK (Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CASK antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CASK Antibody

Binding Specificity: AA 589-616

Predicted Reactivity: H, M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Rat Cask antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 589-616 amino acids from the Central region of rat Cask.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-CASK antibody (ABIN1881710)

Tabuchi, Biederer, Butz, Sudhof: "CASK participates in alternative tripartite complexes in which Mint 1 competes for binding with caskin 1, a novel CASK-binding protein." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 22, Issue 11, pp. 4264-73, (2002) (PubMed).

Chetkovich, Bunn, Kuo, Kawasaki, Kohwi, Bredt: "Postsynaptic targeting of alternative postsynaptic density-95 isoforms by distinct mechanisms." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 22, Issue 15, pp. 6415-25, (2002) (PubMed).

Hsueh, Wang, Yang, Sheng: "Nuclear translocation and transcription regulation by the membrane-associated guanylate kinase CASK/LIN-2." in: Nature, Vol. 404, Issue 6775, pp. 298-302, (2000) (PubMed).

Butz, Okamoto, Südhof: "A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain." in: Cell, Vol. 94, Issue 6, pp. 773-82, (1998) (PubMed).

Hata, Butz, Südhof: "CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 16, Issue 8, pp. 2488-94, (1996) (PubMed).

Target Details for CASK

Target: CASK (Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK))

Alternative Name: Cask

Background: Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TRB1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins, and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.

Molecular Weight: 103259

NCBI Accession: NP_071520

UniProt: Q62915

Pathways: Synaptic Vesicle Exocytosis